An estimated 620,000 people in the UK have a faulty gene that puts them at risk of developing coronary heart disease or sudden death, and most are unaware, a charity has warned.
The British Heart Foundation said the figure was 100,000 more than had been thought and could be even higher.
It said there was now a better grasp of the prevalence of inherited conditions.
A child of someone with an inherited heart condition can have a 50% chance of inheriting it themselves.
The charity warned that the overall figure for those with the faulty gene could be much higher because of as yet undiscovered faulty genes and under-diagnoses.
Each week in the UK, around 12 seemingly healthy people aged 35 or under are victims of sudden cardiac death with no explanation, largely due to undiagnosed heart conditions.
Research has helped to discover many of the faulty genes that cause inherited heart conditions.
This has led to the development of structured genetic testing services for those at highest risk for some of these conditions.
However, the British Heart Foundation says more research is urgently needed.
Inherited heart conditions: What
you need to know
• Many people with an inherited heart condition have no symptoms, but some can develop some warning signs including dizzy spells, palpitations and blackouts
• Screening and genetic testing can help identify problems
• Doctors will suggest you be tested if a family member has been diagnosed with an inherited heart condition, there is a family history of premature deaths or you have been diagnosed with angina or had a heart attack at a young age
• If you are diagnosed with an inherited heart condition, monitoring and treatment can reduce the risk of a sudden heart attack or cardiac arrest
• Speak to your GP if you are concerned
Prof Sir Nilesh Samani, BHF medical director, said: “The reality is that there are hundreds of thousands of people across the UK who are unaware that they could be at risk of sudden death.
“If undetected and untreated, inherited heart conditions can be deadly and they continue to devastate families, often by taking away loved ones without warning.
“We urgently need to fund more research to better understand these heart conditions, make more discoveries, develop new treatments and save more lives.”